GHK-Cu has the following activity on the skin and hair follicles: References Mechanism of Action 1,2 The activity of GHK-Cu is thought to be multifaceted and includes: GHK-Cu has been associated with the upregulation of genes involved in tissue repair, anti-inflammatory signaling, and antioxidant defense, and the downregulation of genes linked to fibrosis and oxidative stress
In the Abca4Rdh8 mouse model, which exhibits defects in atRAL clearance, Chen et al
These findings informed the creation of a unique formulation first validated through an in-vitro cell culture study, which confirmed its ability to activate GLP-1 pathways, reduce the enzyme responsible for breaking it down, and increase receptor activation
Abstract Glucagon-like peptide-1 (GLP-1) is an incretin hormone released from gut enteroendocrine cells that modulates glucose metabolism by controlling insulin excretion and glucagon secretion and inhibits gastric emptying leading to decreased food intake, thus limiting weight gain
If bullous pemphigoid is suspected, JANUVIA should be discontinued and referral to a dermatologist should be considered for diagnosis and appropriate treatment
